MYC and lymphoma: We use two types of lymphoma cells, i.e., drug-sensitive (Eμ-myc/Arf-/-) and drug-resistant (Eμ-myc/p53-/-) cells, which harbor loss-of-function of the alternative reading frame (ARF) protein (cellular response to oncogenic stress) along with the tumor suppressor 53 (p53) gene (DNA repair, growth arrest, and apoptosis), respectively.