We use two types of lymphoma cells, i.e., drug-sensitive (Eμ-myc/Arf-/-) and drug-resistant (Eμ-myc/p53-/-) cells, which harbor loss-of-function of the alternative reading frame (ARF) protein (cellular response to oncogenic stress) along with the tumor suppressor 53 (p53) gene (DNA repair, growth arrest, and apoptosis), respectively. The gene discussed is CDKN2A; the disease is lymphoma.