New insight into benzodiazepine therapy in SPS is provided by immunomodulatory properties of PBR on the outer mitochondrial membrane that suppresses Tumor necrosis factor-induced Vascular cell adhesion protein 1 and Intercellular Adhesion Molecule 1 expression on endothelium14 and prevents Formylmethionyl-leucyl-phenylalanine-induced L-selectin, Platelet endothelial cell adhesion molecule-1 on the neutrophil cell surface.15 Contrary to peripheral immunosuppressive action in microglia, PBR is expressed from the earliest stages of activation and appears to exert proinflammatory function.16 Here, ICAM1 is linked to stiff-person syndrome.