Antibodies against soluble liver antigen (SLA) were first described in 1987 in a specific form of AIH.7 Antibodies to SLA and liver-pancreas antigen were originally defined as different antibodies but subsequently have been identified as the same autoantibody given that they share the same antigenic target.8 Anti-SLA antibodies can be detected by radioimmunoassay, enzyme-linked immunosorbent assays, immunoblotting, or dotblotting assays, rather than by immunofluorescence. This evidence concerns the gene SLA and autoimmune hepatitis.