The native cytosolic antigen or recombinant 50 kDa protein identified as O-phosphoseryl-tRNA: selenocysteinyl-tRNA synthase used in detection assays was confirmed by mass spectrometry with human native antigen in 2010.9,10 It has been suggested that anti-SLA antibody might be a marker of disease severity in patients with AIH.11 Several studies demonstrated that anti-SLA was associated with relapse after corticosteroid therapy.12,13 However, a recent report indicated that anti-SLA may be not associated with treatment response and outcome.14 This evidence concerns the gene SLA and autoimmune hepatitis.