Data regarding AST extracted came from 583 AIH patients (anti-SLA positive in 91 cases and negative in 492 cases), and the analysis showed that the pooled mean AST levels were significantly lower in seropositive patients than in seronegative patients, according to the fixed-effect model (standardized mean difference −0.289, 95% CI −0.514 to −0.064, P = 0.012). This evidence concerns the gene SLA and autoimmune hepatitis.