ENG and neoplasm: CD105 (endoglin) is an 180-kDa homodimeric transmembrane protein overexpressed in proliferating endothelial cells.20 The observations that CD105 was strongly up-regulated in the endothelium within various tumors compared with normal tissues supported the important role of CD105 in the investigation of tumor angiogenesis.21–23 CD105 has been demonstrated to be an endothelial cell proliferation-associated marker and to represent a powerful indicator of neovascularization.20 To the best of our knowledge, CD105-determined MVD has not been studied in KAs.