LRP1 and atherosclerosis: The mechanisms by which macrophage LRP1 modulates the development of atherosclerosis and the extent of vascular remodeling are not fully understood at this time, but may involve LRP1’s ability to regulate the phagocytosis of apoptotic cells [27,28], its ability to regulate the TGF-β signaling pathway [29], or its ability to modulate macrophage migration by coordinating with the integrin Mac-1, tissue-type plasminogen activator and its serpin inhibitor, PAI-1 [30].