In agreement with the connection between Src/PI3K activation and aberrant regulation of cell cycle in human lung cancer cells [13,14], we found that the endogenous phosphorylation levels of Src/PI3K were much higher in cancerous NSCLC cells than that in the normal human bronchial epithelial BEAS-2B cells (S3 Fig). The gene discussed is SRC; the disease is lung carcinoma.