The multiprobe melanoma FISH assay targets the common regions of alterations in melanoma: 6p25 (targeting RREB1), 6q23 (MYB), 11q13 (CCND1), and 9p21 (CDKN2A)33, 34, 35, 36; whereas comparative genomic hybridization (CGH) studies provide a genome wide view of copy number changes37, 38. This evidence concerns the gene RREB1 and melanoma.