We enumerated AE-specific CD8+ T cells in the peripheral blood of 15 HLA-A2+ RA patients submitted to etanercept (of whom 9 would be Rs and 6 would be NRs) by using dextramers of HLA-A*0201 molecules complexed to ACTB266-274, MYH9478-486, MYH9741-749, VIME78-87, or VIME225-233 peptides (Fig 2). This evidence concerns the gene HLA-A and rheumatoid arthritis.