The regulation of TAF9B by sno-miR-28, and the reciprocal repression of the sno-miR host gene by p53, suggests a role for sno-miR-28: p53 feedback in cancer, which supports recent discoveries that a large number of miRNAs interact with the p53 network as an alternative mechanism of the tumour-suppressor activity of p53 [5–17, 19–21, 57]. This evidence concerns the gene TAF9B and neoplasm.