IPA analysis was further performed comparing proteins differentially expressed in healthy BRCA1-mutation carriers vs. healthy controls; in this subset, we obtained 2 predicted networks (Fig 4A): i) Cardiovascular Disease, Metabolic Disease, Cardiac Infarction (Fig 4B) and ii) Organismal Survival, Cell Death and Survival, Cellular Development (Fig 4C). Here, BRCA1 is linked to metabolic disease.