In S. aureus 8325–4 skin infected mice, IgG levels against Efb, EsxA, EsxB, IsaA, IsdA, IsdH, lipase, LukD, LukE, LytM, Nuc, PG, PrsA, SA0104, SSL1 and SSL10 were significantly higher than in mice with placebo skin infection. Here, GLRX5 is linked to skin infection.