More precise and targeted manipulation of these two key reactions became possible through the knockout of genes encoding γ-GCS and GR, respectively, in P. berghei. This offered insights into the potential importance of these two proteins in the animal model malaria species and allows to some extent to conclude also about the regulatory roles of these reactions for the maintenance of GSH redox balance in the human malaria parasites (Figure 1 and Table 1) [66,67,72]. Here, GSR is linked to malaria.