This pilot study is the first demonstration of an effect of morning bromocriptine-QR therapy to improve glycemic control while enabling a reduction in total daily insulin dose requirement in T2DM subjects whose glycemia was inadequately controlled (HbA1c > 7.5%) on metformin plus high-dose (TDID insulin ≥ 65 units/day) MDI insulin therapy. This evidence concerns the gene INS and type 2 diabetes mellitus.