Alternatively, circadian-timed, morning administration of bromocriptine-QR, a quick-release, high absorbing formulation of a potent dopamine D2 receptor agonist, that is approved in the US for the treatment of T2DM appears to be a unique insulin sensitizing therapy with a good safety profile, without risk of weight gain or hypoglycemia and with a potential to reduce adverse cardiovascular risk [21–23]. The gene discussed is DRD2; the disease is type 2 diabetes mellitus.