In insulin resistant states, the normal daily peak in dopaminergic activity at the biological clock (hypothalamic SCN) is diminished and reinstating this peak with systemic, central, or direct (to the SCN itself) dopaminergic agonist reverses the insulin resistance ([28, 36, 37, 44, 45], Cincotta and Luo unpublished data). This evidence concerns the gene INS and Insulin resistance.