NOS3 and type 2 diabetes mellitus: Importantly, circadian timed treatment of spontaneously hypertensive rats (SHR) with bromocriptine has demonstrated improvements in metabolic syndrome parameters including elevated SNS tone, fatty liver, and hepatic inflammation [33], as well as reductions in arterial stiffness and endothelial nitric oxide synthase uncoupling [33], two phenomena commonly observed in patients with T2DM and strongly linked to progression of macrovascular disease [19–21].