The expression of the noncoding Meg3 transcript is severely suppressed in various cancer cell lines and tumor types, while the deletion of the corresponding genome locus leads to aggressive tumors [43]. Meg3 RNA upregulates p53 levels by downregulating Mdm2 levels and promotes angiogenesis by increasing Vegfa and Vegfr1 levels [44, 45]. Here, MEG3 is linked to cancer.