The neurotoxic effects of hypoglycemia are also well understood [8], and there are strong links between insulin and beta amyloid: insulin appears to initiate the production of beta amyloid as well as promote its accumulation through competition for degradation by insulin-degrading enzyme [67]; it may further contribute to amyloid formation through co-secretion of the amyloid-forming peptide amylin with insulin from pancreatic beta cells [65, 69]. The gene discussed is INS; the disease is Hypoglycemia.