RUNX1T1 and acute myeloid leukemia: In addition, chromosomal translocations between the EWSR1 and FLI1 loci and between the AML1 (also known as RUNX1) and ETO (also known as RUNX1T1) loci, which are involved in Ewing’s sarcoma and acute myeloid leukemia (AML), respectively, have been generated by CRISPR in human cell lines [23].