In particular, data from murine studies suggest that the transfer of autologous Treg cells is able to prevent the development of collagen-induced arthritis and colitis, while ex vivo expanded CD4+CD25+ Treg cells can attenuate the development of experimental autoimmune encephalomyelitis and ameliorate type I diabetes [35]. The gene discussed is IL2RA; the disease is experimental autoimmune encephalomyelitis.