Other serum proteins were also found differentially expressed between CCA and BBTD including angiotensinogen (AGT), ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), hemoglobin, zeta (HBZ), keratin-1 (KRT1), keratin-10 (KRT10), and serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), and member 1 (SERPINA1). This evidence concerns the gene ADAMTS3 and cholangiocarcinoma.