Presence of the two fragments of 100 and 130 kDa in the sera of DMD patients as well as LGMD2D patients and in different animal models of DMD (mdx mouse, GRMD dog) and other forms of muscular dystrophy indicates a conserved mechanism of MYOM3 proteolysis and release across species and diseases. Here, MYOM3 is linked to Duchenne muscular dystrophy.