Furthermore, a long-term, sustained restoration of α-sarcoglycan (Sgca) and γ-sarcoglycan (Sgcg) expression was observed following intramuscular gene transfer to muscles of patients with limb-girdle muscular dystrophy types 2D (LGMD2D) (13) and 2C (14) respectively. This evidence concerns the gene SGCG and autosomal recessive limb-girdle muscular dystrophy type 2D.