In dystroglycanopathy, the pial basement membrane is disrupted due to the lack of dystroglycan function, and neurons over-migrate beyond the breached basement membrane, resulting in the formation of a neuronal heterotopia and perturbation of the six-layered structure of the neocortex19. The gene discussed is DAG1; the disease is neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.