DAG1 and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan: Glial fibrillary acidic protein (GFAP)-Cre- or Nestin-Cre-mediated deletion of dystroglycan in the central nervous system recapitulated the structural brain defects found in patients with dystroglycanopathy, such as basement membrane disruption, neuronal migration defects, and neuronal heterotopia formation20, 23.