The inhibition of L-LTP induced by SB431542 (20 μM) thirty min before a strong tetanus (n = 7/7; 138.45 ± 23.01 vs. 211.72 ± 7.46% of baseline slope 120 min after tetanus) was rescued when slices were concomitantly perfused with TGF-β1 (10 ng/ml) for 10 minutes before a strong tetanus (n = 7; 196.58 ± 25.69% of baseline slope 120 min after tetanus; ANOVA: F(2, 18) = 10.495, p = 0.001 among the 3 groups; Fig. 2a) confirming that the impairment of LTP was specifically mediated by TGF-β1 inhibition. The gene discussed is TGFB1; the disease is tetanus.