TGFB1 and pulmonary fibrosis: To demonstrate whether the transcriptional downregulation of PINK1 by TGFβ1 in normal human lung fibroblasts is recapitulated in animal models of pulmonary fibrosis, we exposed mice to 3 × 108 PFU of replication-deficient adenovirus encoding either GFP (AdGFP) or active TGFβ1 (AdTGFβ1).