We found that seven downstream proteins (heat shock protein HSP 90-alpha [HSP90AA1], [MBP], [MKI67], phosphoglycerate mutase 1 [PGAM1], phosphoglycerate kinase 1 [PGK1], pyruvate kinase PKM, and ADP/ATP translocase 2 [SLC25A5]) were upregulated in AD tissue and were upstream regulators of Myc. This evidence concerns the gene PKM and Alzheimer disease.