PIK3CA and cancer: Fibroblast growth factor receptors (FGFRs) are a family of transmembrane tyrosine kinase receptors belonging to the fibroblast growth factor (FGF) pathway, that upon activation promote cell proliferation, migration, angiogenesis, and survival in cancer cells by the activation of the Ras-dependent MAPK signaling pathway and PI3K/Akt/mTOR.