Romero et al. assessed RAGE levels in amniotic fluid in five groups of pregnant women: (1) women with a gestational age between 14 and 18 weeks of an uncomplicated pregnancy; (2) pregnancies at term; (3) women in labor at term; (4) pregnant women threatened with premature labor with unruptured fetal membranes; and (5) women diagnosed with pPROM, depending on the presence or absence of intrauterine infection [39]. Here, AGER is linked to preterm premature rupture of the membranes.