POU5F1 and neoplasm: ITE significantly reduced the POU5F1 mRNA levels in tumours, the tumour volumes as well as the tumour weights (Fig. 4a), and there was a positive correlation between the POU5F1 mRNA level/tumour volume (Fig. 4b) and the POU5F1 mRNA level/tumour weight when all the mouse samples were analysed together (Fig. 4c).