SRC and melanoma: Also, it has been proposed that upon Ca2+ entry in effector-stimulated cells, CaM residing in lipid rafts interacts in a Ca2+-dependent manner with and activates c-Src, and in turn c-Src phosphorylates and inhibits protein phosphatase 2A (PP2A), preventing in this manner its inhibitory action on Akt and henceforth promoting melanoma tumor growth [22].