IQCB1 and cyst: Together with the broad resemblance between NPHP5/6/8 expression patterns and typical cilia genes (Rink et al., 2009; Glazer et al., 2010) (Figure 5—figure supplement 1), these data conclusively demonstrate that knockdown of planarian NPHP-genes causes not only protonephridial cyst formation, but also structural defects in cilia.