As with CD4+ T cells, CD8+ T cell methylation at CpG_10 and CpG_9 was associated with JIA (CpG_10: 5.9% (95% CI 2.5–9.3%) vs 11.6% (95% CI 7.1–16.2%), t-test p = 0.037; CpG_9: 15.2% (95% CI 9.1–21.4%) vs 25.5% (95% CI 17.7–33.3%), t-test p = 0.034). Here, CD4 is linked to juvenile idiopathic arthritis.