Each standard deviation (SD) increment of plasma cystatin C was significantly related to increased risk of CAD during follow-up (Odds Ratio, 95% confidence interval) 1.28, 1.16–1.42 (P = 1.8x10-6) after age and sex adjustment and 1.20, 1.07–1.34 (P = 0.001) after full risk factor adjustment according to model 2. This evidence concerns the gene CST3 and coronary artery disorder.