In the present study, the results of qRT-PCR revealed that the mRNA level of MMP-9 but not those of PAI-1, MMP-1, or MMP-2 (data not shown) were consistent with the migration and invasion activities of both MUC1 gene silenced and MUC1-overexpressing HCC cells. The gene discussed is SERPINE1; the disease is hepatocellular carcinoma.