To verify the role of MIF and GDF-15 in iPSC-MSCs-CdM for the treatment of Dox-induced cardiomyopathy, we compared the cardioprotective effects of iPSC-MSCs-CdM with immunodepletion of MIF and GDF-15 in iPSC-MSCs-CdM in a mouse model of AIC. This evidence concerns the gene GDF15 and cardiomyopathy.