MTOR and ischemia: Moreover, the arteritis of the blood vessels may lead to ischemia in CNS or myocardial infarction through decreased nutrient and oxygen supply by damaged arteries and may further induce an already genetically modulated DDIT4L in neurons or cardiac myocytes, which in turn inhibit mTOR signaling and activate autophagy (genes LAMTOR3 and AP3B2 code for adaptor proteins in the lysosome-endosome system) and lead to apoptosis or necrosis [59].