Overall, the role of EAAT2 polymorphisms in schizophrenia have not been examined in depth, with the exception of SNP rs4354668,58, 60, 61, 62 which has also been explored in relation to other disorders.60, 63, 64, 65 SNP rs4354668 is a T to G polymorphism located 181 base pairs from the EAAT2 gene transcription start site. This evidence concerns the gene SLC1A2 and schizophrenia.