In addition, we measured CDK5 activity in two specific subregions of the PFC implicated in mood and symptoms related to mood disorders, namely the subgenual anterior cingulate cortex (BA25) and the inferior frontal gyrus (corresponding to BA44, 45 and 47) to avoid a possibility of overlooking the phenomena specific to these brain areas.49, 50, 51, 52 We found that the CDK5 activity was elevated in BA25 of these depressive subjects, while the activity in their PFC, HIPPO and inferior frontal gyrus was similar to that of control subjects. This evidence concerns the gene CDK5 and mood disorder.