To validate the association of WEE1 rs3910384 G/G with the efficacy of DNA-damaging agents, 264 patients with advanced NSCLC who received platinum-gemcitabine chemotherapy were subjected to WEE1 rs3829254, rs3910384, rs4370932, and rs1049403 genotyping. The gene discussed is WEE1; the disease is non-small cell lung carcinoma.