SDHB and lung cancer: Using the PGL4 WEE1 haplotype promoter luciferase reporter assay, we confirmed that WEE1 haplotype promoters can mediate allele-specific transcription of WEE1 in lung cancer cell lines H1299 and A549 after treatment with the DNA-damaging chemotherapy agents cisplatin and gemcitabine (Fig. 4C).