This might be due to a combination of the potent anti-proliferative effect of PI3K/mTOR inhibition in NB cells and the induction of autophagy [5], although it should be pointed out that autophagy in NB is controversially discussed, as in most tumor entities, and can be a survival mechanism as well as a cell death enhancer (for example [49, 50]). Here, MTOR is linked to neuroblastoma.