Interestingly, NB lacks the mutations in PI3K signaling that characterize GBM and other tumors and a role for PI3K in NB was first considered due to its close association with the mycN oncogene [41] and its prominent role downstream of growth factor-initiated signaling, such as IGF-1 and IGF-2 [42]. The gene discussed is IGF2; the disease is neuroblastoma.