ERBB2 and colorectal cancer: Examples of single-antigen plasmid-based vaccines include human prostatic acid phosphatase protein for patients with prostate cancer [113], human epidermal growth factor receptor-2 (HER-2/neu), protooncogene with low-doses of GM-CSF intradermally for patients with metastatic breast cancer [114], and modified carcinoembryonic antigen (CEA) gene fused to a promiscuous tetanus toxoid for colorectal cancer [115].