CSF2 and neoplasm: Another advantage is its viral capability to carry a large load of transgenes, such as a pro-drug-activating gene thymidine kinase enzyme that enhances tumor lysis when ganciclovir medication is subsequently administered intravenously (suicide gene) [45]; therapeutic immunomodulatory transgenes that augment the antitumor immune response (such as talimogene laherparepvec) (OncoVEX GM-CSF) [47]; and antiangiogenic genes to suppress tumor vasculature [48].