SLC22A4 and gastrointestinal stromal tumor: Furthermore, among the patients of gastrointestinal stromal tumors (GIST) who received imatinib treatment, the time to progression was recently shown to be significantly improved in the carriers of the C allele of an OCTN1 polymorphism (rs1050152) as well as in carriers of minor alleles of two OCTN2 polymorphisms (rs2631367 and rs2631372), suggesting the activities of OCTN1 and OCTN2 as a predictor of chemotherapeutic efficacy of imatinib[86].