TFRC and neoplasm: 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) bearing LNPs encapsulating HER2-siRNAs and containing HK peptides (to enhance the escape from the endosomes) coupled to a single-chain antibody fragment (scFv) that binds to transferrin receptors (elevated on the surface of many cancerous cells), have been targeted to tumor xenograft and inhibited tumor progression [30, 77].