Exclusion criteria were: subjects under 18 years, the presence of malignancy, infectious diseases or diseases that may affect HSD11B1 gene expression or was described to be associated with its polymorphic variants such as Cushing’s syndrome, osteoporosis, cortisone reductase deficiency (CRD), Alzheimer’s disease and polycystic ovary syndrome (PCOS). This evidence concerns the gene HSD11B1 and polycystic ovary syndrome.