In another study, increased omental HSD11B1 activity in women submitted to a gynecological surgery was associated with larger omental adipocytes, increased lipolysis and lipoprotein lipase activity, decreased high-density lipoprotein cholesterol and adiponectin levels, and an increased homeostasis model assessment of insulin resistance index compared to those with decreased omental activity of this enzyme [38]. Here, HSD11B1 is linked to Insulin resistance.