TTR and intrahepatic cholangiocarcinoma: Low expression of LKB1 is an independent risk factor for both OS (HR = 1.824; 95% CI: 0.404–2.377; p < 0.001) and TTR (HR = 1.782: 95% CI: 1.355–2.348; p < 0.001) for ICC patients (Figure 2D).