In addition, over-expression of different miRNAs, including miR-130a and miR-590-5p, and the inferred activation of TGFB1 may explain the down-regulation of FAS. Similarly, up-regulation of miR-520c-3p detected in the HD-MM may causes inhibition of TP73 and CCND2. The latter are strongly down-regulated in HD-MM also for the inhibitory activity induced by over-expression of miR-520c-3p, miR-526b and miR-135a. The gene discussed is CCND2; the disease is Miyoshi myopathy.