Indeed we found that SDE-genes identified in previous step are related to STAT3 pathways including genes involved in cell cycle progression (Cyclin D1, D2, and c-Myc), cell survival (Bcl-xL, Bcl-2, Mcl-1), angiogenesis (HIF1α, VEGF), cancer inflammation (NF-KB, IL-6). This evidence concerns the gene CCND1 and cancer.