CCND2 and neoplasm: Conversely, in nHD-MM patients, TGFβ acts mostly as tumor-suppressor because it's down-regulation is associated, in our model, with the up-regulation of FAS and CCND2. It is well known that Fas-mediated apoptosis plays an important role in activation-induced cell death, T-cell-induced cytotoxicity, immune privilege, tumor surveillance [48] and can also mediate a variety of non-apoptotic activities especially during tumor-genesis and tumor progression in Fas-resistant tumor cells [49].