Although Cyclins D are the class of cell-cycle regulators more involved in MM pathogenesis, our analysis shows up-regulation of Cyclin E2 which is related, with an effect not predicted by IPA, to downregulation of HIC1. Finally, NUPR1, a protein related to the high mobility group of TRs that is a key player in the cellular stress response and is involved in metastasis, is activated in HD-MM patients according to the target activation or inhibition. Here, HIC1 is linked to Miyoshi myopathy.