Previous studies have shown that among CD34+ pDC cases, both the pDC lineage-committed and the minimally differentiated blast cell population coexisting in individual patients, share the same chromosomal aberrations [23, 24], which suggests that both cell populations arise from a common ancestral leukemia cell, and that the pDC-lineage component may represent the more differentiated blast cell compartment. Here, CD34 is linked to leukemia.