In fact, at present it is now well-established that tumor cells from BPDCN do express markers which have been classically related to other cell lineages such as CD33, TdT, CD79a, CD2 and CD7 [10, 11], and evidences exist about a broad range of atypical phenotypic profiles in a substantial proportion of cases (up to more than one third of cases), including absence of CD56 [12] and CD4 [13]. Here, NCAM1 is linked to neoplasm.