The MMP-3:TIMP-3 ratio also increased 2.9-fold in RASFC (0.15 to 0.44, p <0.05) and 5.2-fold in ex vivo RA synovial explants (41 to 215, p <0.01) (Fig. 2b, 2c (v)). Here, TIMP3 is linked to rheumatoid arthritis.