TIMP3 and rheumatoid arthritis: TIMP-3 secretion from RA ex vivo explants significantly decreased 2.4-fold (basal 21 ng/mL compared to Pam3CSK4 8.6 ng/mL, p <0.05) (Fig. 2c (iii)), with no significant change observed in RASFC (p = 0.09) (Fig. 2b (iii)).