In addition, Saber et al. 2011, demonstrated in RASFC and RA explant cultures that TLR2 activation induces angiogenic tube formation, adhesion molecule expression and growth factor expression, an effect that was in part mediated through the angiopoietin 2 (Ang2)/Tie-2 pathway [11]. The gene discussed is TLR2; the disease is rheumatoid arthritis.