Ishizawa et al. reported that well- or moderately differentiated HCC mostly displayed uniform or partial type fluorescence, poorly differentiated HCC mostly displayed rim type fluorescence, and metastatic tumors mostly displayed rim type fluorescence [10] in part because the degree of NTCP and OATP8 expression varied according to tumor differentiation [22]. Here, SLCO1B3 is linked to hepatocellular carcinoma.