Recent study has demonstrated that the activation of glucagon-like peptide-1 receptor can inhibit vascular smooth muscle cells calcification through NF-κB/RANKL signaling [33] and chronic stimulation of AT4 and inhibition of AT2 receptors reverse diabetes-induced endothelial dysfunction [34], which could also play a vital role in renal sodium handling. The gene discussed is GLP1R; the disease is endothelial dysfunction.