Similarly, treatment of Caski and CSCC1 cancer cells with entinostat resulted in a higher production of CCL2, IL-8 and CXCL9 by the cancer cells when stimulated with IFN-γ and TNF-α than dimethylsulphoxide carrier control-treated cells (Fig. 5i; Supplementary Fig. 5d). The gene discussed is TNF; the disease is cancer.