INS and Hypoglycemia: In the study published by Eliaschewitz et al. [8], while equivalence was found for the two treatment groups in terms of changes in HbA1c levels from baseline (p = 0.795), a 27 % lower relative risk (RR) of hypoglycemia was demonstrated for insulin glargine in comparison to NPH insulin (RR, 1.27; 95 % CI, 1.03–1.57).