Similar results were obtained using a threshold < 3.9 mmol/L with a proportion of patients with hypoglycemia of 25.1 % vs. 22.6 % (OR 1.15; 95%CI 0.70-1.90) in period 1 during treatment with insulin glargine vs. NPH insulin and 25.0 % vs. 23.9 % (OR 1.06; 95%CI 0.63-1.78) in period 2. The gene discussed is INS; the disease is Hypoglycemia.